Higuchi connors phase solubility techniques.

The phase solubility curve was a typical AL-type curve, as described in solubility diagrams by Higuchi and Connors. A regression coefficient (R 2) exceeding 0.99 and slope value (0.0732) of less than 1 revealed the formation of the KME/HP-β-CD system with a 1:1 stoichiometry. The Ks of KME/HP-β-CD were calculated based on the …according to Higuchi and Connors (10). Briefly, an excess amount of paracetamol ... Phase solubility techniques. In: Reilley CN. (ed.) Advances in Analytical ...After equilibrium was attained, the suspensions were filtered through 0.45 µm cellulose membrane filter, the filtrates diluted with the mobile phase and analyzed by HPLC. The apparent complexation constants for drug/cyclodextrin complexes (K 1:1) were determined according to the phase-solubility method of Higuchi and Connors.Phase solubility study. Phase-solubility study is a traditional and useful approach not only to determine the value of the stability constant, but also to give insight into the stoichiometry of the equilibrium. The practical and phenomenological implications of phase solubility study were developed by Higuchi and Connons (Higuchi & Connors ...

Solubility diagrams were obtained according to Higuchi and Connors. 11 . Excess ... Phase solubility techniques, in: C. Reilly (Ed.), Advances in. Analytical ...Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. About: The article was published on 1965-01-01 and is currently open access. It has received 2363 citation (s) till now. The article focuses on the topic (s): Phase (matter) & Solubility.

This was explained by the solubilization theory of Higuchi and Connors. The solubility analysis of the ternary drug/competitor/CyD systems may be particularly useful for determination of the stability constant of a drug whose physicochemical and spectroscopic analyses are difficult, because they can be calculated by monitoring the solubility ...Phase solubility of GO/β-CD complex. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). Excess amounts of GO were added to 10 ml of water solution of β-CD at different concentrations ranging from 0 to 9.5 mM.

31 Ağu 2017 ... The phase solubility studies were carried out to study the effect of cyclodextrins according to the method described by Higuchi and Connors. The ...Detection of inclusion complexation was done in solution by means of phase solubility analysis, mass spectrometry, and 1 H nuclear magnetic resonance (1 H-NMR) spectroscopic studies, and in solid state using differential scanning calorimetry (DSC), powder x-ray diffractometry (X-RD), scanning electron microscopy (SEM), and in vitro dissolution ...11 Tem 2017 ... Higuchi T, Connors KA. Phase solubility techniques. Advances in Analytical Chemistry and Instrumen- tation. New York, pp. 117–212 ...to be considered in designing and carrying out these solubility studies. Experimental Methods Saturation Shake-Flask Method The shake-flask method is based on the phase solubility technique that was developed 40 years ago and is still the most reliable and widely used method for solubility measurement today (Higuchi and Connors, 1965). …

Phase solubility analysis The solubility measurements were performed according to the The phase solubility diagram of SMX and HP-␤-CD, obtained by method of Higuchi and Connors [22] in aqueous solutions contain- plotting the changes in guest solubility as a function of HP-␤-CD ing different concentrations of HP-␤-CD, ranging from 14.3 mM ...

to be considered in designing and carrying out these solubility studies. Experimental Methods Saturation Shake-Flask Method The shake-flask method is based on the phase solubility technique that was developed 40 years ago and is still the most reliable and widely used method for solubility measurement today (Higuchi and Connors, 1965). …

The apparent solubility of the substrates (adenine, guanosine, acyclovir, or triamterene) was appreciably increased by forming complexes with the ligands (vitamins, amino acids, or other ligand). Apparent association constants (K a ) values were measured at 25°C in pH 7 phosphate buffer using phase solubility analysis.7 Ağu 2017 ... All other reagents used are of analytical grade. Phase solubility study (Higuchi Connors method). Phase solubility studies were performed ...Phase solubility of GO/β-CD complex. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). Excess amounts of GO were added to 10 ml of water solution of β-CD at different concentrations ranging from 0 to 9.5 mM.According to the Higuchi and Connors classification [6], the phase solubility diagram for the repaglinide – HP- β-CD inclusion complex is A type, which indicates the formation of a soluble complex.All experiments were repeated three times. According to the linear part of the phase solubility curve, the stability constant (Kc) was calculated using the Higuchi-Connors equation. (1) K c = S l o p e S 0 × (1-S l o p e) S 0: the solubility of NAR without β-CD. The solubilizing efficiency of β-CD was evaluated by the complexation efficiency ...2.3 Phase solubility studies. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). 21 Excess amounts of EO were added to CD solutions at different concentrations ranging from 0 to 40mM. The mixtures were shaken overnight at 25°C and then filtered through a 0.45 μm membrane filter.T. Higuchi, A. Connors Published 1965 Chemistry No Paper Link Available Save to Library Create Alert Cite 2,644 Citations Citation Type More Filters Environmentally friendly stability-indicating HPLC method for the determination of isotretinoin in commercial products and solubility samples

7 May 2015 ... ... solubility method (Higuchi and Connors 1965). Figure 1 shows the phase ... Higuchi T, Connors KA (1965) Phase-solubility techniques. Adv Anal ...In this regard, the well-known solubility diagram design (T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212) should be done in order to obtain information about the drug solubility in presence of increasing CD concentrations.The shake-fl ask method proposed by Higuchi and Connors is the most reliable and widely used solubility measurement method. ... K. A. Connors, Phase-solubility techniques, Adv. Anal. Chem. Instr ...Phase Solubility Study Figure No. 3. Phase-solubility profiles and classification of complexes. Higuchi and Connors [22] have classified complexes based their effect on substrate solubility as indicated by phase-solubility profiles (Figure 3). A-type phase-solubility profiles are obtained when the solubility of the substrate (i.e., drug ...HIGHLIGHTS Enhanced curcumin solubility up to 190 fold higher than pure curcumin was investigated The phase solubility results of curcumin range from 5.7×10-4 M-1 and 7.8×10-4 M-1 at 25 and 37 ...The most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that the drug solubility ...

Phase-solubility measurements. Phase-solubility measurements were carried out according to the method of Higuchi and Connors.14 Excess amount of 5-NI. ( ...

Phase solubility studies The phase solubility studies were carried out according to the method of Higuchi and Connors (Jansook et al. 2018 ; Higuchi & Connors 1965 ). Briefly, an excess of KME was added to 200 μL aqueous solutions of different HP-β-CD concentrations (1, 2, 4, 6, 8, and 10 mM).Citation University of Kansas. Kenneth Spencer Research Library Personal papers of Takeru Higuchi (PP 359) Articles arranged alphabetically by title: Higuchi A-Z; Higuchi et. al. A-Z Higuchi and Connors, "Phase-Solubility Techniques,", 1964 Dates Creation: 1964 Collapse All Get at Spencer Box: 11, Folder: 35 (Mixed Materials) Repository Details(1970). Phase Solubility Analysis. C R C Critical Reviews in Analytical Chemistry: Vol. 1, No. 2, pp. 193-215.Abstract. The effect of polymers and various drugs on the solubility of β-cyclodextrin (βCD) was determined. The apparent stability constant (Kc) of the drug-βCD complex was calculated from the phase-solubility diagrams. The water solubility of βCD was determined to be 1.9% (w/v), but addition of 0.25-1% (w/v) of polyvinylpyrrolidone (PVP ...2 May 2011 ... It has to be noted that in the Higuchi and Connors method applied, Kc was obtained from the apparent cholesterol solubility, which comprises ...Abstract. Levemopamil was solubilized by varying the concentration of hydroxypropyl- β -cyclodextrin (HP β CD) and by the alteration of pH. The drug molecule has two sites for possible complexation with HP β CD, creating the possibility of either 1:1 or 1:2 complexation. The solubility as a function of HP β CD concentration of the charged ...Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, pp. 117–212. Google Scholar Abstract. This current work has been conducted mainly to increase solubility and drug release properties for high hydrophobic Dentatin (DEN) by incorporation it into …In both cases, concentrations between 0.2% to 20% w/v of CDs in water were used, and the phase solubility studies were carried out according to the method reported by Higuchi and Connors . An excess amount of the berberine chloride was added to the aqueous solutions containing increasing concentrations of RMβCD (1.52 to 152.67 mM) or HPβCD (1 ...7 Ağu 2017 ... All other reagents used are of analytical grade. Phase solubility study (Higuchi Connors method). Phase solubility studies were performed ...

Determination of stoichiometry of host and guest by phase solubility method. The stoichiometry of host and guest was established by phase solubility technique described by Higuchi-Connors [24, 25]. Briefly, an excess weighed amount of EFV was added to series of HP-β-CD solutions (3–15 mM).

Higuchi and Connors, "Phase-Solubility Techniques,", 1964, Box: 11, Folder: 35. Personal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer Research Library. Copy to clipboard

Phase solubility techniques. T. Higuchi, A. Connors. Published 1965. Chemistry. No Paper Link Available. Save to Library. Create Alert. Cite. 2,644 Citations. Citation Type. More Filters. Environmentally friendly stability-indicating HPLC method for the …2.2. Phase solubility study. Analysis of phase solubility was implemented based on the method from Higuchi and Connors (Citation 1965). CAT (excess amount) was mixed with 20 mL of β-CD aqueous solutions in different concentration levels …The phase solubility diagram (Fig. 2) showed that the solubility of cholesterol increased linearly with increasing β-CD concentration from 0 to 18 mmol/L (R 2 > 0.99). The phase solubility diagram was defined as the A L -type phase based on the early research of Higuchi and Connors (1965) , revealing the formation of inclusion complex …T. Higuchi and K. A. Connors. Phase solubility techniques. Adv. Anal. Chem. Instrum. 4:117-212 (1965). ... In S. Yalkowsky (ed.), Techniques of Solubilization of Drugs, Marcel Dekker, New York, 1981, pp. 135-149. Google Scholar T. Higuchi and H. Kristiansen. Binding specificity between small organic solutes in aqueous solution ...2.3 Phase solubility studies. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). 21 Excess amounts of EO were added to CD solutions at different concentrations ranging from 0 to 40mM. The mixtures were shaken overnight at 25°C and then filtered through a 0.45 μm membrane filter.Phase Solubility Studies. Phase solubility studies were carried out at room temperature (21 ± 1°C) following the method of Higuchi and Connors . Excess amounts of OME were weighed in glass flasks to which 10 ml of boric/borate buffer pH = 10 were added. These flasks contained increasing amounts of βCD (0–1.5%, w/v) or MβCD (0–5%, w/v).Phase solubility test Phase solubility studies were performed according to the methods described by Higuchi and Connors ( Higuchi & Connors, 1965 ). Excess amounts of quinestrol was suspended in a 0.1 mol/L phosphate buffer solution (pH 7.0) containing increasing amounts of DM-β-CD (from 0 mM to 10.00 mM).The apparent solubility of the substrates (adenine, guanosine, acyclovir, or triamterene) was appreciably increased by forming complexes with the ligands (vitamins, amino acids, …Phase solubility studies. Solubility measurements were performed in triplicate using the method reported by Higuchi and Connors (Higuchi et al., 1965). An excess amount of ALLO was added to the aqueous solutions of each carrier containing increasing concentrations of the individual carrier (i.e., 0, 1, 5, and 10 % w/v).Phase solubility stud ies were performed according to the method . reported by H iguchi and Connors [14]. Ex cess drug ... Higuchi T, Connors K. Phase-solubility techniques. Adv AnalPhase solubility behavior was studied according to the method proposed by Higuchi and Connors ... Phase solubility techniques. Adv. Anal Chem Instrum 1965; 4: 117 ...

The phase solubility study of CDL with PSC[4]arene and PSC[6]arene were executed according to Higuchi and Connors . Phase solubility studies were accomplished at 27 °C temperature, in triplicate. Excess quantity of CDL (250 mg) was added into different conical flasks containing 150 mL aqueous solutions of PSC[4]arene and PSC[6]arene at …A Way to Increase the Bioaccesibility and Photostability of Roflumilast, a COPD Treatment, by Cyclodextrin Monomers. In vitro digestion showed that CDs protect the drug during digestion and even improve its bioaccessibility, and points to the need to protect roflumilast from light, suggesting that tablets containing the drug might be reformulated.Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. About: The article was published on 1965-01-01 and is currently open access. It has received 2363 citation (s) till now. The article focuses on the topic (s): Phase (matter) & Solubility.Instagram:https://instagram. underground gas explosionrivals247idea 504 ada comparison chartcrimson and blue day ku Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, pp. 117–212. Google Scholar parliamentary procedure meeting scriptchange my mind gif T. Higuchi and K. A. Connors. Phase solubility techniques. Adv. Anal. Chem. Instrum. 4:117–212 (1965). ... In S. Yalkowsky (ed.), Techniques of Solubilization of Drugs, Marcel Dekker, New York, 1981, pp. 135–149. Google Scholar T. Higuchi and H. Kristiansen. Binding specificity between small organic solutes in aqueous solution ...method described by Higuchi & Connors et al [18]. Excess NSF (100 mg) was added to a 50 m L . ... [18] Higuchi T and Connors K A 1965 Phase solubility techniques Advances in Analyt ical Chemistry . craigs list yuba city AAPS PharmaSciTech 2005;6:464–72. 18. Higuchi T, Connors KA. Phase solubility techniques. Adv Anal Chem Instrum 1965;4:117–212. 19. Higuchi T, Kristiansen H. Binding specificity between small organic solutes in aqueous Solution, Classification of some solutes into two groups according to binding tendencies. J Pharm Sei 1970;59:1601–8. 20.Types of phase-solubility diagrams according to Higuchi and Connors [11] showing how the total drug solubility changes with increasing CD concentration.Phase-solubility measurementsPhase-solubility measurements were carried out according to the method of Higuchi and Connors. 14 Excess amount of 5-NI (5 mg) was added to 5 mL of deionized water containing increasing amounts of βCD and DM-βCD (ranging from 0 to 0.010 M).